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Real-Time Metabolic Imaging. Made Simple.
On-site, push-button production of metabolic imaging agents
Dynamic metabolite signals are below the detection threshold of standard MRI. POLARIS uses hyperpolarization to enhance these signals by more than 10,000x, transforming existing MRI infrastructure into a real-time, non-invasive metabolic imaging platform.
With POLARIS, metabolic imaging agents are produced on-site, making advanced metabolic imaging simple, reliable, and scalable.
Real-Time Metabolic Imaging in 3 Simple Steps
Prepare
Take a precursor metabolic agent (organic molecule natural to the body), e.g., 13C enriched pyruvate
Polarize
Use POLARIS to amplify the MRI signal of the metabolic agent by >10,000x through spin hyperpolarization
Scan
Inject the hyperpolarized agent and measure its metabolism using standard MRI
POLARIS minimizes variability through standardized kits and automated polarization and purification.
Within 3 minutes, a hyperpolarized dose is ready for injection and imaging.
From system readiness to dose initiation, all steps are managed through a clear, intuitive touchscreen interface.
Explore how POLARIS could fit into your workflow
Key Benefits
- High throughput (up to 3 doses/hour)
- Convenient, room temperature processing
- Small footprint, minimal infrastructure adjustment
- Simple, robust workflow with ready-to-use kits
An End-to-End Solution for Rapid Setup in Your Lab
Polarizer
Consumables
Active Ingredients
Ready-to-use 13C-pyruvate precursor and catalyst
Parahydrogen Cylinders
Support
Service & Maintenance
Consulting & Training
Research Collaborations
Grant Applications
Image Acquisition & Analysis
Testimonial
Experience with POLARIS in Preclinical Use
"POLARIS joined our lab like a shooting star! Being able to quickly obtain a strong and reproducible hyperpolarized pyruvate signal was our dream for a long time.
POLARIS Preclinical is integrated in our standard preclinical metabolic imaging workflows with hyperpolarized pyruvate in rodent studies. The system's ease of use and small footprint support ongoing preclinical studies in oncology, physiology and neurology.
We are looking forward to continue working with it together with the incredible team from NVision!"
Prof. Dr. Franz Schilling
Professor for Biomedical Magnetic Resonance,
Technical University of Munich
Technical University of Munich
Obtain High-Quality Hyperpolarized Signal With PHIP
POLARIS uses parahydrogen-induced polarization (PHIP) to produce hyperpolarized metabolic imaging agents. PHIP enables strong, robust signal enhancement for real-time metabolic imaging within a streamlined, high-throughput workflow.
With POLARIS, PHIP produces a metabolic signal comparable to d-DNP.
Data generated by:
Luca Nagel, Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany
1H-MRI
Coronal slice of a subcutaneous MATBIII breast cancer model (rat) surrounded by gel for B0 homogeneity.
PHIP Lac/Pyr
Lactate/pyruvate ratio measured from 3D dynamic bSSFP after injection of PHIP pyruvate.
d-DNP Lac/Pyr
Lactate/pyruvate ratio after injection of d-DNP pyruvate (same location, same sequence as PHIP).