POLARIS:Product

Real-Time Metabolic Imaging. Made Simple.

On-site, push-button production of metabolic imaging agents

Robust

Scalable

Easy-to-Use

Dynamic metabolite signals are below the detection threshold of standard MRI. POLARIS uses hyperpolarization to enhance these signals by more than 10,000x, transforming existing MRI infrastructure into a real-time, non-invasive metabolic imaging platform.

With POLARIS, metabolic imaging agents are produced on-site, making advanced metabolic imaging simple, reliable, and scalable.

Real-Time Metabolic Imaging in 3 Simple Steps

Prepare

Take a precursor metabolic agent (organic molecule natural to the body), e.g., 13C enriched pyruvate

Polarize

Use POLARIS to amplify the MRI signal of the metabolic agent by >10,000x through spin hyperpolarization

Scan

Inject the hyperpolarized agent and measure its metabolism using standard MRI

POLARIS minimizes variability through standardized kits and automated polarization and purification.

Within 3 minutes, a hyperpolarized dose is ready for injection and imaging.

From system readiness to dose initiation, all steps are managed through a clear, intuitive touchscreen interface.

Explore how POLARIS could fit into your workflow

Schedule a Technical Scoping

Key Benefits

High throughput (up to 3 doses/hour)
Convenient, room temperature processing
Small footprint, minimal infrastructure adjustment
Simple, robust workflow with ready-to-use kits

An End-to-End Solution for Rapid Setup in Your Lab

Polarizer

Consumables

Active Ingredients

Ready-to-use 13C-pyruvate precursor and catalyst

Parahydrogen Cylinders

Support

Service & Maintenance

Consulting & Training

Research Collaborations

Grant Applications

Image Acquisition & Analysis

Testimonial

Experience with POLARIS in Preclinical Use

"POLARIS joined our lab like a shooting star! Being able to quickly obtain a strong and reproducible hyperpolarized pyruvate signal was our dream for a long time.

POLARIS Preclinical is integrated in our standard preclinical metabolic imaging workflows with hyperpolarized pyruvate in rodent studies. The system's ease of use and small footprint support ongoing preclinical studies in oncology, physiology and neurology.

We are looking forward to continue working with it together with the incredible team from NVision!"

Prof. Dr. Franz Schilling

Professor for Biomedical Magnetic Resonance,
Technical University of Munich

Technical Specifications

POLARIS Preclinical

Probe

[1-13C] pyruvate

Coming soon: ɑ-Ketoglutarate and ɑ-Ketoisocaproate

Produced Dose

3 options available: (a) 0.8 mL at 80 mM, (b) 1 mL at 160mM, (c) 2 mL at 80 mM

Dimensions

H 192 cm / W 87 cm / D 80 cm

Certification

Meets relevant US / EU regulations for laboratory equipment

Obtain High-Quality Hyperpolarized Signal With PHIP

POLARIS uses parahydrogen-induced polarization (PHIP) to produce hyperpolarized metabolic imaging agents. PHIP enables strong, robust signal enhancement for real-time metabolic imaging within a streamlined, high-throughput workflow.

With POLARIS, PHIP produces a metabolic signal comparable to d-DNP.

Data generated by:

Luca Nagel, Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany

1H-MRI

Coronal slice of a subcutaneous MATBIII breast cancer model (rat) surrounded by gel for B0 homogeneity.

PHIP Lac/Pyr

Lactate/pyruvate ratio measured from 3D dynamic bSSFP after injection of PHIP pyruvate.

d-DNP Lac/Pyr

Lactate/pyruvate ratio after injection of d-DNP pyruvate (same location, same sequence as PHIP).