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Quantum-Enhanced Metabolic MRI
NVision leverages the latest advances in quantum physics to enable real-time metabolic imaging on standard MRIs, providing actionable insights to support drug development and clinical decision-making.
This is POLARIS
POLARIS amplifies the signal of natural metabolites through molecular spin control (“hyperpolarization”), enabling their rapid and precise measurement with standard MRI.
- High throughput
- Convenient, room temperature operations
- Small footprint, minimal infrastructure adjustment
- Simple, robust workflow
Order POLARIS for preclinical use now
We have developed a unique quantum-enhanced platform that transforms existing MRIs into powerful metabolic imagers at scale
Prepare
Take a precursor metabolic agent (organic molecule natural to the body), e.g., 13C enriched pyruvate
Polarize
Use POLARIS to amplify the MRI signal of the metabolic agent by >10,000x through spin hyperpolarization
Scan
Inject the hyperpolarized agent and measure its metabolism using standard MRI
Metabolic MRI provides unprecedented insights at cellular level
Standard MRI
Detects anatomical and structural changes
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Metabolic MRI
Detects early changes in key pathways at the cellular level
Metabolic MRI adds critical information for assessing disease activity based on metabolism.
In cancer, tumors exhibit altered metabolism that correlates with disease aggressiveness and response to treatment
Metabolic insights at cellular level may allow early assessment of response to therapy.
Changes at tissue level
Typically, changes are visible only months after onset of treatment.
Changes at cellular level
Effective treatment induces metabolic response within days, visible with Metabolic MRI.
Metabolic MRI: Potential to optimize drug development and monitor treatment response
Metabolic MRI may provide feedback on drug efficacy within days. This can be leveraged to adjust ineffective drug protocols (dosing, schedule, combinations) for better and faster outcomes.
Patients
Metabolic MRI pre-treatment
Treatment
~7 days
Metabolic MRI post-treatment
Early feedback on efficacy
Adjusted protocol
High impact across many medical fields
Oncology
Cardiology
Hepatology
Nephrology
Inflammation
Neurology
POLARIS is currently available as a preclinical research system; development toward a system for investigational clinical use is ongoing. Hyperpolarized imaging agents, including [1-¹³C] pyruvate, are investigational and have not received regulatory approval for routine clinical application.